SYSTEMS APPROACHES TO STUDY CANCER METASTASIS AND GENE REGULATION
ABOUT US
Welcome to the Dasgupta Lab Homepage. Our lab is based in the Department of Cell Stress Biology at Roswell Park Comprehensive Cancer Center, Buffalo, NY, a National Cancer Institute (NCI) designated comprehensive cancer center. We also have adjunct affiliation with Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, and located in the heart of Buffalo Niagara Medical Campus (BNMC). Our laboratory focusses on defining the underlying mechanisms that promote tumor progression and metastasis. We take a systems biology approach investigating metabolic pathways, genetic and epigenetic regulation, and immune evasion mechanisms that selectively sustain the growth and progression of metastatic tumors. State of art facilities such as proteomics, genomics, and metabolomics along with molecular biology techniques are widely used in multiple model systems of Genetically Engineered Mouse Models (GEMMs), Patient-Derived Xenograft (PDX), and syngeneic tumor models.
RESEARCH DIRECTIONS
DISCOVERING METABOLIC DYSREGULATION IN CANCER
DEFINING TRANSCRIPTIONAL AND EPIGENETIC REGULATION
DECODING TUMOR MICROENVIRONMENT AND IMMUNE RESPONSE
SELECTED PUBLICATIONS
RECENT LAB NEWS
BUFFALO, N.Y. — Metastasis, or the spread of cancer cells from a primary tumor to distant organs, lacks effective treatment options and remains a major cause of cancer-related deaths. To better understand....
While prostate cancer originates within the prostate, metastasis, or the spread of a tumor from the site of origin to other organs, remains a leading cause of death ....
